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        p53 (Acetyl Lys382) rabbit pAb
        
                    ES1122
                    
        
                        
        
                            
        
                                規(guī)格：
                                價格：
                            
        
                                                        
        
                                50μL
                                ￥1280.00
                            
        
                                                        
        
                                100μL
                                ￥1980.00
                            
        
                                                    
        
                    
        
                    
                
        
            
        
        
        

                
        
            
        
                
        Overview
                    
        
                
        
                    
        
                        
        
                            
        
                                
        
                                    
        
                                        Product name:
                                        p53 (Acetyl Lys382) rabbit pAb
                                    
        
                                                                            
        
                                            Reactivity:
                                            Human;Rat;Mouse;
                                        
        
                                                                                
        
                                            Alternative Names:
                                            TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53
                                        
        
                                                                                
        
                                           Source:
                                           Rabbit
                                           
                                        
        
                                                                                
        
                                           Dilutions:
                                           Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
                                           
                                        
        
                                                                                
        
                                           Immunogen:
                                           Synthesized acetyl-peptide derived from the human p53 around the acetylation site of K382.
                                           
                                        
        
                                                                                
        
                                           Storage:
                                           -20°C/1 year
                                           
                                        
        
                                                                                
        
                                           Clonality:
                                           Polyclonal
                                           
                                        
        
                                                                                
        
                                           Isotype:
                                           IgG
                                           
                                        
        
                                                                                
        
                                           Concentration:
                                           1 mg/ml
                                           
                                        
        
                                                                                
        
                                           Observed Band:
                                           53kD
                                           
                                        
        
                                                                                
        
                                           GeneID:
                                           7157
                                           
                                        
        
                                                                                
        
                                           Human Swiss-Prot No:
                                           P04637
                                           
                                        
        
                                                                                
        
                                           Cellular localization:
                                           Cytoplasm . Nucleus . Nucleus, PML body . Endoplasmic reticulum . Mitochondrion matrix . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Recruited into PML bodies together with CHEK2 (PubMed:12810724). Translocates to mitochondria upon oxidative stress (PubMed:22726440). Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408). .; [Isoform 1]: Nucleus . Cytoplasm. Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4.; [Isoform 2]: Nucleus. Cytoplasm. Localized mainly in the nucleus with minor staining in the cytoplasm.; [Isoform 3]: Nucleus. Cytoplasm. Localized in the nucleus in most cells but found in the cytoplasm in some cells.; [Isoform 4]: Nucleus. Cytoplasm. Predominantly nuclear but translocates to the cy
                                           
                                        
        
                                                                                
        
                                           Background:
                                           tumor protein p53(TP53) Homo sapiens    This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013],
                                           
                                        
        
                                                                        
        
                            
        
                                                    
        
                    
        
                
        
            
        
                        
                    
        
    
        
    




        
    
        
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