Product name: |
Cleaved-Plasma Kallikrein HC (R390) rabbit pAb |
Reactivity: |
Human;Rat;Mouse; |
Alternative Names: |
KLKB1; KLK3; Plasma kallikrein; Fletcher factor; Kininogenin; Plasma prekallikrein |
Source: |
Rabbit |
Dilutions: |
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
Immunogen: |
The antiserum was produced against synthesized peptide derived from human KLKB1. AA range:341-390 |
Storage: |
-20°C/1 year |
Clonality: |
Polyclonal |
Isotype: |
IgG |
Concentration: |
1 mg/ml |
Observed Band: |
45kD |
GeneID: |
3818 |
Human Swiss-Prot No: |
P03952 |
Cellular localization: |
Secreted. |
Background: |
This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016], |