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        Claudin-2 (8H11) Mouse mAb
        
                    EM1403
                    
        
                        
        
                            
        
                                規(guī)格：
                                價(jià)格：
                            
        
                                                        
        
                                50μL
                                ￥1280.00
                            
        
                                                        
        
                                100μL
                                ￥1980.00
                            
        
                                                    
        
                    
        
                    
                
        
            
        
        
        

                
        
            
        
                
        Overview
                    
        
                
        
                    
        
                        
        
                            
        
                                
        
                                    
        
                                        Product name:
                                        Claudin-2 (8H11) Mouse mAb
                                    
        
                                                                            
        
                                            Reactivity:
                                            Human, Rat, Mouse
                                        
        
                                                                                
        
                                           Source:
                                           Mouse
                                           
                                        
        
                                                                                
        
                                           Dilutions:
                                           WB 1:1,000-2,000?? IHC:1;100-1:200
                                           
                                        
        
                                                                                
        
                                           Immunogen:
                                           Synthetic Peptide
                                           
                                        
        
                                                                                
        
                                           Storage:
                                           PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
                                           
                                        
        
                                                                                
        
                                           Clonality:
                                           Monoclonal
                                           
                                        
        
                                                                                
        
                                           Isotype:
                                           IgG1
                                           
                                        
        
                                                                                
        
                                           Concentration:
                                           1mg/mL
                                           
                                        
        
                                                                                
        
                                           Observed Band:
                                           25kDa
                                           
                                        
        
                                                                                
        
                                           GeneID:
                                           9075
                                           
                                        
        
                                                                                
        
                                           Human Swiss-Prot No:
                                           P57739
                                           
                                        
        
                                                                                
        
                                           Cellular localization:
                                           Cell junction,tight junction,Cell membrane
                                           
                                        
        
                                                                                
        
                                           Background:
                                           The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer . Claudin-2 is expressed primarily in the proximal tubule of the normal mammalian kidney, where it regulates transepithelial ion (e.g., Na+, Cl-) reabsorption . Increased expression of Claudin-2 has been reported in some cancer cell lines , including A549 lung adenocarcinoma cells, where its nuclear distribution was positively associated with enhanced proliferation .
                                           
                                        
        
                                                                        
        
                            
        
                                                    
        
                    
        
                
        
            
        
                        
                    
        
    
        
    




        
    
        
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