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        MLKL (8H7) Mouse mAb
        
                    EM1328
                    
        
                        
        
                            
        
                                規(guī)格：
                                價(jià)格：
                            
        
                                                        
        
                                50μL
                                ￥1280.00
                            
        
                                                        
        
                                100μL
                                ￥1980.00
                            
        
                                                    
        
                    
        
                    
                
        
            
        
        
        

                
        
            
        
                
        Overview
                    
        
                
        
                    
        
                        
        
                            
        
                                
        
                                    
        
                                        Product name:
                                        MLKL (8H7) Mouse mAb
                                    
        
                                                                            
        
                                            Reactivity:
                                            Human
                                        
        
                                                                                
        
                                            Alternative Names:
                                            Mixed lineage kinase domain like protein, FLJ34389
                                        
        
                                                                                
        
                                           Source:
                                           Mouse
                                           
                                        
        
                                                                                
        
                                           Dilutions:
                                           IHC 1:100-200
                                           
                                        
        
                                                                                
        
                                           Immunogen:
                                           Synthetic Peptide
                                           
                                        
        
                                                                                
        
                                           Storage:
                                           PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
                                           
                                        
        
                                                                                
        
                                           Clonality:
                                           Monoclonal
                                           
                                        
        
                                                                                
        
                                           Isotype:
                                           IgG1
                                           
                                        
        
                                                                                
        
                                           Concentration:
                                           1mg/mL
                                           
                                        
        
                                                                                
        
                                           Observed Band:
                                           54kDa
                                           
                                        
        
                                                                                
        
                                           GeneID:
                                           197259
                                           
                                        
        
                                                                                
        
                                           Human Swiss-Prot No:
                                           Q8NB16
                                           
                                        
        
                                                                                
        
                                           Cellular localization:
                                           Cell membrane,?Cytoplasm,?Membrane
                                           
                                        
        
                                                                                
        
                                           Background:
                                           Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227, which recruits MLKL and leads to its phosphorylation at Thr357 and Ser358.
                                           
                                        
        
                                                                        
        
                            
        
                                                    
        
                    
        
                
        
            
        
                        
                    
        
    
        
    




        
    
        
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