| Product name: |
a-actinin (4A12) Mouse mAb |
| Reactivity: |
Human, Rat, Mouse |
| Alternative Names: |
actinin 1 smooth muscle antibody, actinin alpha 1 antibody, ACTN 1 antibody, FLJ40884 antibody |
| Source: |
Mouse |
| Dilutions: |
IHC 1:100-200 |
| Immunogen: |
Recombinant Protein |
| Storage: |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles. |
| Clonality: |
Monoclonal |
| Isotype: |
IgG1 |
| Concentration: |
1mg/mL |
| Observed Band: |
103kDa |
| GeneID: |
87 |
| Human Swiss-Prot No: |
P12814 |
| Cellular localization: |
Cell junction,?Cell membrane,?Cell projection,?Cytoplasm,?Cytoskeleton,?Membrane |
| Background: |
α-Actinin belongs to the spectrin family of cytoskeletal proteins. α-Actinin is necessary for the attachment of actin filaments to the Z-lines in skeletal muscle cells, and to the dense bodies in smooth muscle cells. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinated contractions between sarcomeres in the horizontal axis. |
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