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        NFkB p65 Mouse mAb
        EM1111
        規(guī)格: 價(jià)格:
        50μL ¥1280.00
        100μL ¥1980.00

        Overview 文獻(xiàn)

        Product name: NFkB p65 Mouse mAb
        Reactivity: Human, Rat, Mouse
        Alternative Names: NFKB3, p65, RELA, Transcription factor p65
        Source: Mouse
        Dilutions: WB 1:500-2,000 IP 1:200 IF 1:100-200 IHC 1:200-500
        Immunogen: Recombinant Protein
        Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
        Clonality: Monoclonal
        Isotype: IgG1
        Concentration: 1mg/mL
        Observed Band: 65kDa
        GeneID: 5970
        Human Swiss-Prot No: Q04206
        Cellular localization: Cytoplasm,?Nucleus
        Background: NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection.
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